PROF. FABIO ZOBI
Our Medicinal Inorganic Chemistry Research Group works at the interface between inorganic chemistry, organometallic chemistry, medicinal chemistry, chemical biology and biology. Projects undertaken in our laboratory fundamentally aim at answering open scientific questions of current interest in the fields above. We are also interested in developing new imaging techniques and identifying clinically useful compounds which should ultimately be employed to ameliorate different human pathologies. Generally speaking, our scientific pursuit involves the preparation, characterization and application (for biological or medicinal purposes) of metal-based complexes and the surface functionalization of bio-inspired materials.
Department of Chemistry
PhD Students Seminars
New synthetic routes to aerobically stable and substitutionally labile α-diimine rhenium(I) dicarbonyl complexes. Read more about it here.
Rhenium complexes possessing remarkable anticancer, antiangiogenic and antimetastatic activity in vivo (zebrafish-human HCT-116 xenograft model). Read more about it here.
Read more about it here.
Rhenium complexes exhibiting potent in vivo (zebrafish-S. aureus infection model) antimicrobial activity at doses as low as 350 ng/mL. Read more about it here.
Heme Oxygenase-1/Carbon Monoxide System
and Embryonic Stem Cell Differentiation
and Maturation into Cardiomyocytes.
Dr. Hagir Suliman and Dr. Claude Piantadosi (Duke University Medical Center, USA) provide evidence that our B12-ReCORM-2 molecule has the capacity to augment cardiomyogenesis via a defined mitochondrial pathway and that the same has unique therapeutic potential for targeting embryonic stem cell maturation in cardiac disease. Read more about it here.
Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes. Cytoxicity of hybrid multifunctional drug delivery system enhanced by photoactivation of the microalgae surface. Read more about it here.
Our group prepared a new bio-inspired material designed for targeted delivery of poorly water-soluble inorganic anticancer drugs, with a focus on colorectal cancer. Read more about it here. See video.
Three-Dimensional Mid-Infrared Tomographic Imaging of Endogenous and Exogenous Molecules in a Single Intact Cell with Subcellular Resolution.
A method and protocols to obtain tomographic 3D images of the endogenous and exogenous cellular distribution of molecules. Read more about it here.