PROF. FABIO ZOBI

Our Medicinal Inorganic Chemistry Research Group works at the interface between inorganic chemistry, organometallic chemistry, medicinal chemistry, chemical biology and biology. Projects undertaken in our laboratory fundamentally aim at answering open scientific questions of current interest in the fields above. We are also interested in developing new imaging techniques and identifying clinically useful compounds which should ultimately be employed to ameliorate different human pathologies. Generally speaking, our scientific pursuit involves the preparation, characterization and application (for biological or medicinal purposes) of metal-based complexes and the surface functionalization of bio-inspired materials.

International Chemistry
Conferences 
Department of Chemistry
Seminars

UPCOMING EVENTS

PhD Students Seminars
Group Meetings

ICCC2020

Rimini, 05-10.07.2020
EuroBIC2020
Reykjavik, 16-20.08.2020
hqdefault.jpg

LATEST RESEARCH

Aerobically stable and substitutionally labile α-diimine rhenium dicarbonyl complexes.

New synthetic routes to aerobically stable and substitutionally labile α-diimine rhenium(I) dicarbonyl complexes. Read more about it here.

Identification of novel potent and non-toxic anticancer, anti-angiogenic and antimetastatic rhenium complexes against colorectal carcinoma.

Rhenium complexes possessing remarkable anticancer, antiangiogenic and antimetastatic activity in vivo (zebrafish-human HCT-116 xenograft model). Read more about it here.

Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA).

Rhenium complexes exhibiting potent in vivo (zebrafish-S. aureus infection model) antimicrobial activity at doses as low as 350 ng/mL. Read more about it here.

Heme Oxygenase-1/Carbon Monoxide System
and Embryonic Stem Cell Differentiation
and Maturation into Cardiomyocytes.

Dr. Hagir Suliman and Dr. Claude Piantadosi (Duke University Medical Center, USA) provide evidence that our B12-ReCORM-2 molecule has the capacity to augment cardiomyogenesis via a defined mitochondrial pathway and that the same has unique therapeutic potential for targeting embryonic stem cell maturation in cardiac disease. Read more about it here.

Slow-​targeted release of a ruthenium anticancer agent from vitamin B12 functionalized marine diatom microalgae.

Our group prepared a new bio-inspired material designed for targeted delivery of poorly water-soluble inorganic anticancer drugs, with a focus on colorectal cancer. Read more about it here. See video.

Three-Dimensional Mid-Infrared Tomographic Imaging of Endogenous and Exogenous Molecules in a Single Intact Cell with Subcellular Resolution.

A method and protocols to obtain tomographic 3D images of the endogenous and exogenous cellular distribution of molecules. Read more about it here.

This site was designed with the
.com
website builder. Create your website today.
Start Now